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MMP-2 Silencing through siRNA Loaded Positively-Charged Nanoparticles (AcPEI-NPs) Counteracts Chondrocyte De-Differentiation

The abnormal matrix remodeling process, as well as inflammation, angiogenesis, and tumor metastasis, are related to an increase in the synthesis and secretion of matrix metalloproteinases (MMPs), the zinc-dependent proteolytic endopeptidases. Recent studies have evidenced MMPs’ role in osteoarthriti...

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Detalles Bibliográficos
Autores principales:	Conte, Raffaele, Finicelli, Mauro, Borrone, Alessia, Margarucci, Sabrina, Peluso, Gianfranco, Calarco, Anna, Bosetti, Michela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007186/ https://www.ncbi.nlm.nih.gov/pubmed/36904410 http://dx.doi.org/10.3390/polym15051172

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