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Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells
Our unique multiplexed imaging assays employing FRET biosensors have previously detected that γ-secretase processes APP C99 primarily in late endosomes and lysosomes in live/intact neurons. Moreover we have shown that Aβ peptides are enriched in the same subcellular loci. Given that γ-secretase is i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007619/ https://www.ncbi.nlm.nih.gov/pubmed/36904854 http://dx.doi.org/10.3390/s23052651 |