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Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells

Our unique multiplexed imaging assays employing FRET biosensors have previously detected that γ-secretase processes APP C99 primarily in late endosomes and lysosomes in live/intact neurons. Moreover we have shown that Aβ peptides are enriched in the same subcellular loci. Given that γ-secretase is i...

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Detalles Bibliográficos
Autores principales:	Houser, Mei C. Q., Mitchell, Shane P. C., Sinha, Priyanka, Lundin, Brianna, Berezovska, Oksana, Maesako, Masato
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007619/ https://www.ncbi.nlm.nih.gov/pubmed/36904854 http://dx.doi.org/10.3390/s23052651

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