HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy

BACKGROUND: Microglial activation-mediated neuroinflammation is one of the essential pathogenic mechanisms of sepsis-associated encephalopathy (SAE). Mounting evidence suggests that high mobility group box-1 protein (HMGB1) plays a pivotal role in neuroinflammation and SAE, yet the mechanism by whic...

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Detalles Bibliográficos
Autores principales: Yin, Xiao-Yu, Tang, Xiao-Hui, Wang, Shi-Xu, Zhao, Yong-Chang, Jia, Min, Yang, Jian-Jun, Ji, Mu-Huo, Shen, Jin-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007818/
https://www.ncbi.nlm.nih.gov/pubmed/36906561
http://dx.doi.org/10.1186/s12974-023-02756-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007818/
https://www.ncbi.nlm.nih.gov/pubmed/36906561
http://dx.doi.org/10.1186/s12974-023-02756-3

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