Synthesis, Molecular Dynamics Simulation, and In-vitro Antitumor Activity of Quinazoline-2,4,6-triamine Derivatives as Novel EGFR Tyrosine Kinase Inhibitors

BACKGROUND: Developing a potent and safe scaffold is challenging in anti-cancer drug discovery. OBJECTIVES: The study focused on developing novel series of compounds based on the inhibition of epidermal growth factor receptor tyrosine kinase (EGFR-TK) as one of the most promising compounds in cancer...

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Detalles Bibliográficos
Autores principales: Nili Ahmadabadi, Maryam, Rezaee, Elham, Nematpour, Manijeh, Karami, Leila, Mokhtari, Shaya, Kobarfard, Farzad, Tabatabai, Sayyed Abbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brieflands 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008000/
https://www.ncbi.nlm.nih.gov/pubmed/36915409
http://dx.doi.org/10.5812/ijpr-133840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008000/
https://www.ncbi.nlm.nih.gov/pubmed/36915409
http://dx.doi.org/10.5812/ijpr-133840

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