Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial

BACKGROUND: Profound lymphopenia is an independent predictor of adverse clinical outcomes in sepsis. Interleukin-7 (IL-7) is essential for lymphocyte proliferation and survival. A previous phase II study showed that CYT107, a glycosylated recombinant human IL-7, administered intramuscularly reversed...

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Detalles Bibliográficos
Autores principales: Daix, Thomas, Mathonnet, Armelle, Brakenridge, Scott, Dequin, Pierre-François, Mira, Jean-Paul, Berbille, Frederique, Morre, Michel, Jeannet, Robin, Blood, Teresa, Unsinger, Jacqueline, Blood, Jane, Walton, Andrew, Moldawer, Lyle L., Hotchkiss, Richard, François, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008152/
https://www.ncbi.nlm.nih.gov/pubmed/36906875
http://dx.doi.org/10.1186/s13613-023-01109-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008152/
https://www.ncbi.nlm.nih.gov/pubmed/36906875
http://dx.doi.org/10.1186/s13613-023-01109-w

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