Rapid rEcognition of COrticosteRoiD resistant or sensitive Sepsis (RECORDS): study protocol for a multicentre, placebo-controlled, biomarker-guided, adaptive Bayesian design basket trial

INTRODUCTION: Corticosteroids affect variably survival in sepsis trials, suggesting heterogeneity in patients’ response to corticosteroids. The RECORDS (Rapid rEcognition of COrticosteRoiD resistant or sensitive Sepsis) trial aimed at defining endotypes associated with adults with sepsis responsiven...

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Detalles Bibliográficos
Autores principales: Fleuriet, Jérôme, Heming, Nicholas, Meziani, Ferhat, Reignier, Jean, Declerq, Pierre-Louis, Mercier, Emmanuelle, Muller, Grégoire, Colin, Gwenhaël, Monnet, Xavier, Robine, Adrien, Siami, Shidasp, Uhel, Fabrice, Quenot, Jean-Pierre, Plantefeve, Gaetan, Badie, Julio, Schneider, Francis, Cerf, Charles, Troché, Gilles, Monchi, Mehran, Mira, Jean-Paul, Francois, Bruno, Lamiae, Grimaldi, Chevret, Sylvie, Annane, Djillali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Intensive Care
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008229/
https://www.ncbi.nlm.nih.gov/pubmed/36898751
http://dx.doi.org/10.1136/bmjopen-2022-066496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008229/
https://www.ncbi.nlm.nih.gov/pubmed/36898751
http://dx.doi.org/10.1136/bmjopen-2022-066496

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