Autocatalytic base editing for RNA-responsive translational control

Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics. To this end, here we engineer programmable single-transcript RNA sensors in which adenosine deaminases acting on RNA (ADARs) autocatalytically conver...

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Detalles Bibliográficos
Autores principales: Gayet, Raphaël V., Ilia, Katherine, Razavi, Shiva, Tippens, Nathaniel D., Lalwani, Makoto A., Zhang, Kehan, Chen, Jack X., Chen, Jonathan C., Vargas-Asencio, Jose, Collins, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008589/
https://www.ncbi.nlm.nih.gov/pubmed/36906659
http://dx.doi.org/10.1038/s41467-023-36851-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008589/
https://www.ncbi.nlm.nih.gov/pubmed/36906659
http://dx.doi.org/10.1038/s41467-023-36851-z

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