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Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies
Despite the success of targeted therapies in cancer treatment, therapy-induced resistance remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via phenotypic switching driven by intrinsic or induced cell plasticity. Several reversible mechanisms have been proposed to...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008648/ https://www.ncbi.nlm.nih.gov/pubmed/36906600 http://dx.doi.org/10.1038/s41392-023-01383-x |
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author | Shi, Zhen-Duo Pang, Kun Wu, Zhuo-Xun Dong, Yang Hao, Lin Qin, Jia-Xin Wang, Wei Chen, Zhe-Sheng Han, Cong-Hui |
author_facet | Shi, Zhen-Duo Pang, Kun Wu, Zhuo-Xun Dong, Yang Hao, Lin Qin, Jia-Xin Wang, Wei Chen, Zhe-Sheng Han, Cong-Hui |
author_sort | Shi, Zhen-Duo |
collection | PubMed |
description | Despite the success of targeted therapies in cancer treatment, therapy-induced resistance remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via phenotypic switching driven by intrinsic or induced cell plasticity. Several reversible mechanisms have been proposed to circumvent tumor cell plasticity, including epigenetic modifications, regulation of transcription factors, activation or suppression of key signaling pathways, as well as modification of the tumor environment. Epithelial-to-mesenchymal transition, tumor cell and cancer stem cell formation also serve as roads towards tumor cell plasticity. Corresponding treatment strategies have recently been developed that either target plasticity-related mechanisms or employ combination treatments. In this review, we delineate the formation of tumor cell plasticity and its manipulation of tumor evasion from targeted therapy. We discuss the non-genetic mechanisms of targeted drug-induced tumor cell plasticity in various types of tumors and provide insights into the contribution of tumor cell plasticity to acquired drug resistance. New therapeutic strategies such as inhibition or reversal of tumor cell plasticity are also presented. We also discuss the multitude of clinical trials that are ongoing worldwide with the intention of improving clinical outcomes. These advances provide a direction for developing novel therapeutic strategies and combination therapy regimens that target tumor cell plasticity. |
format | Online Article Text |
id | pubmed-10008648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100086482023-03-13 Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies Shi, Zhen-Duo Pang, Kun Wu, Zhuo-Xun Dong, Yang Hao, Lin Qin, Jia-Xin Wang, Wei Chen, Zhe-Sheng Han, Cong-Hui Signal Transduct Target Ther Review Article Despite the success of targeted therapies in cancer treatment, therapy-induced resistance remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via phenotypic switching driven by intrinsic or induced cell plasticity. Several reversible mechanisms have been proposed to circumvent tumor cell plasticity, including epigenetic modifications, regulation of transcription factors, activation or suppression of key signaling pathways, as well as modification of the tumor environment. Epithelial-to-mesenchymal transition, tumor cell and cancer stem cell formation also serve as roads towards tumor cell plasticity. Corresponding treatment strategies have recently been developed that either target plasticity-related mechanisms or employ combination treatments. In this review, we delineate the formation of tumor cell plasticity and its manipulation of tumor evasion from targeted therapy. We discuss the non-genetic mechanisms of targeted drug-induced tumor cell plasticity in various types of tumors and provide insights into the contribution of tumor cell plasticity to acquired drug resistance. New therapeutic strategies such as inhibition or reversal of tumor cell plasticity are also presented. We also discuss the multitude of clinical trials that are ongoing worldwide with the intention of improving clinical outcomes. These advances provide a direction for developing novel therapeutic strategies and combination therapy regimens that target tumor cell plasticity. Nature Publishing Group UK 2023-03-11 /pmc/articles/PMC10008648/ /pubmed/36906600 http://dx.doi.org/10.1038/s41392-023-01383-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Shi, Zhen-Duo Pang, Kun Wu, Zhuo-Xun Dong, Yang Hao, Lin Qin, Jia-Xin Wang, Wei Chen, Zhe-Sheng Han, Cong-Hui Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies |
title | Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies |
title_full | Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies |
title_fullStr | Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies |
title_full_unstemmed | Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies |
title_short | Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies |
title_sort | tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008648/ https://www.ncbi.nlm.nih.gov/pubmed/36906600 http://dx.doi.org/10.1038/s41392-023-01383-x |
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