Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer

Inflammation and metabolic reprogramming are hallmarks of cancer. How inflammation regulates cancer metabolism remains poorly understood. In this study, we found that 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL), the enzyme that catalyzes the catabolism of leucine and promotes the synthesis of keton...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhong, Chenxi, Xiong, Guosheng, Yang, Haitang, Du, Xiaohua, Du, Jiankui, Yao, Feng, Fang, Wentao, Deng, Yuezhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008690/
https://www.ncbi.nlm.nih.gov/pubmed/36923932
http://dx.doi.org/10.7150/ijbs.82015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008690/
https://www.ncbi.nlm.nih.gov/pubmed/36923932
http://dx.doi.org/10.7150/ijbs.82015

Ejemplares similares