Single-cell resolution reveals RalA GTPase expanding hematopoietic stem cells and facilitating of BCR-ABL1-driven leukemogenesis in a CRISPR/Cas9 gene editing mouse model

BCR-ABL oncogene-mediated Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) is suggested to originate from leukemic stem cells (LSCs); however, factors regulating self-renewal of LSC and normal hematopoietic stem cells (HSCs) are largely unclear. Here, we show that RalA, a small...

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Detalles Bibliográficos
Autores principales: Yin, Zhao, Su, Rui, Ge, Lanlan, Wang, Xiuyuan, Yang, Juhua, Huang, Guiping, Li, Chuting, Liu, Yanjun, Zhang, Keda, Deng, Lan, Fei, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008703/
https://www.ncbi.nlm.nih.gov/pubmed/36923939
http://dx.doi.org/10.7150/ijbs.76993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008703/
https://www.ncbi.nlm.nih.gov/pubmed/36923939
http://dx.doi.org/10.7150/ijbs.76993

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