Mapping the energy landscape of PROTAC-mediated protein-protein interactions

A principal challenge in computational modeling of macromolecules is the vast conformational space that arises out of large numbers of atomic degrees of freedom. Recently, growing interest in building predictive models of complexes mediated by Proteolysis Targeting Chimeras (PROTACs) has led to the...

Descripción completa

Detalles Bibliográficos
Autores principales: Villegas, José A., Vaid, Tasneem M., Johnson, Michael E., Moore, Terry W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008833/
https://www.ncbi.nlm.nih.gov/pubmed/36923472
http://dx.doi.org/10.1016/j.csbj.2023.02.049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008833/
https://www.ncbi.nlm.nih.gov/pubmed/36923472
http://dx.doi.org/10.1016/j.csbj.2023.02.049

Ejemplares similares