Lactate exposure shapes the metabolic and transcriptomic profile of CD8+ T cells

INTRODUCTION: CD8+ T cells infiltrate virtually every tissue to find and destroy infected or mutated cells. They often traverse varying oxygen levels and nutrient-deprived microenvironments. High glycolytic activity in local tissues can result in significant exposure of cytotoxic T cells to the lact...

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Detalles Bibliográficos
Autores principales: Barbieri, Laura, Veliça, Pedro, Gameiro, Paulo A., Cunha, Pedro P., Foskolou, Iosifina P., Rullman, Eric, Bargiela, David, Johnson, Randall S., Rundqvist, Helene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008868/
https://www.ncbi.nlm.nih.gov/pubmed/36923405
http://dx.doi.org/10.3389/fimmu.2023.1101433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008868/
https://www.ncbi.nlm.nih.gov/pubmed/36923405
http://dx.doi.org/10.3389/fimmu.2023.1101433

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