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Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability

Chronic pain is highly prevalent and remains a significant unmet global medical need. As part of a search for modulatory genes that confer pain resilience, we have studied two family cohorts where one individual reported much less pain than other family members that share the same pathogenic gain-of...

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Detalles Bibliográficos
Autores principales: Estacion, Mark, Liu, Shujun, Cheng, Xiaoyang, Dib-Hajj, Sulayman, Waxman, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008904/
https://www.ncbi.nlm.nih.gov/pubmed/36923357
http://dx.doi.org/10.3389/fphar.2023.1138556