A genome–wide CRISPR activation screen identifies SCREEM a novel SNAI1 super-enhancer demarcated by eRNAs

The genome is pervasively transcribed to produce a vast array of non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides and are best known for their ability to regulate gene expression. Enhancer RNAs (eRNAs) are subclass of lncRNAs that are synthesized from e...

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Detalles Bibliográficos
Autores principales: Uthaya Kumar, Dinesh Babu, Yurieva, Marina, Grassmann, Jessica, Kozhaya, Lina, McBride, Caleb Dante, Unutmaz, Derya, Williams, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009272/
https://www.ncbi.nlm.nih.gov/pubmed/36923642
http://dx.doi.org/10.3389/fmolb.2023.1110445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009272/
https://www.ncbi.nlm.nih.gov/pubmed/36923642
http://dx.doi.org/10.3389/fmolb.2023.1110445

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