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In vivo modulation of endogenous gene expression via CRISPR/Cas9-mediated 3’UTR editing
The 3' untranslated regions (UTRs) modulate gene expression levels by regulating mRNA stability and translation. We previously showed that the replacement of the negative regulatory elements from the 3'UTR of glial cell line-derived neurotrophic factor (GDNF) resulted in increased endogeno...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009458/ https://www.ncbi.nlm.nih.gov/pubmed/36923835 http://dx.doi.org/10.1016/j.heliyon.2023.e13844 |