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In vivo modulation of endogenous gene expression via CRISPR/Cas9-mediated 3’UTR editing

The 3' untranslated regions (UTRs) modulate gene expression levels by regulating mRNA stability and translation. We previously showed that the replacement of the negative regulatory elements from the 3'UTR of glial cell line-derived neurotrophic factor (GDNF) resulted in increased endogeno...

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Detalles Bibliográficos
Autores principales:	Mätlik, Kärt, Olfat, Soophie, Cowlishaw, Mark Cary, Moreno, Eva Domenech, Ollila, Saara, Andressoo, Jaan-Olle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009458/ https://www.ncbi.nlm.nih.gov/pubmed/36923835 http://dx.doi.org/10.1016/j.heliyon.2023.e13844

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