Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation

Epigenetically switched, proliferative vascular smooth muscle cells (SMCs) form neointima, engendering stenotic diseases. Histone-3 lysine-27 trimethylation (H3K27me3) and acetylation (H3K27ac) marks are associated with gene repression and activation, respectively. The polycomb protein embryonic ect...

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Detalles Bibliográficos
Autores principales: Zhang, Mengxue, Li, Jing, Wang, Qingwei, Urabe, Go, Tang, Runze, Huang, Yitao, Mosquera, Jose Verdezoto, Kent, K. Craig, Wang, Bowen, Miller, Clint L., Guo, Lian-Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009644/
https://www.ncbi.nlm.nih.gov/pubmed/36923952
http://dx.doi.org/10.1016/j.omtn.2023.02.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009644/
https://www.ncbi.nlm.nih.gov/pubmed/36923952
http://dx.doi.org/10.1016/j.omtn.2023.02.024

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