p53 regulates the effects of DAPT on Rac1 activation and migration of non-small-cell lung cancer cells

The use of γ-secretase inhibitors to inhibit the activation of Notch receptors can effectively inhibit the malignant process of tumors. Here, we demonstrate that p53 can modulate the effect of DAPT (a γ-secretase inhibitor) on the activation of small GTPase Rac1, thereby affecting cell migration of...

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Detalles Bibliográficos
Autores principales: Liu, Lei, Xu, Hong, Shi, Yue, Cui, Jie, Wu, Jinxia, Li, Shibao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009732/
https://www.ncbi.nlm.nih.gov/pubmed/36923886
http://dx.doi.org/10.1016/j.heliyon.2023.e14169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009732/
https://www.ncbi.nlm.nih.gov/pubmed/36923886
http://dx.doi.org/10.1016/j.heliyon.2023.e14169

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