Multitarget-Directed Gallium(III) Tris(acyl-pyrazolonate) Complexes Induce Ferroptosis in Cancer Cells via Dysregulation of Cell Redox Homeostasis and Inhibition of the Mevalonate Pathway

[Image: see text] A series of Ga(Q(n))(3) coordination compounds have been synthesized, where HQ(n) is 1-phenyl-3-methyl-4-RC(=O)-pyrazolo-5-one. The complexes have been characterized through analytical data, NMR and IR spectroscopy, ESI mass spectrometry, elemental analysis, X-ray crystallography,...

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Detalles Bibliográficos
Autores principales: Romani, Daphne, Marchetti, Fabio, Di Nicola, Corrado, Cuccioloni, Massimiliano, Gong, Chunmei, Eleuteri, Anna Maria, Galindo, Agustín, Fadaei-Tirani, Farzaneh, Nabissi, Massimo, Pettinari, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009752/
https://www.ncbi.nlm.nih.gov/pubmed/36802330
http://dx.doi.org/10.1021/acs.jmedchem.2c01374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009752/
https://www.ncbi.nlm.nih.gov/pubmed/36802330
http://dx.doi.org/10.1021/acs.jmedchem.2c01374

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