Cargando…

Multitarget-Directed Gallium(III) Tris(acyl-pyrazolonate) Complexes Induce Ferroptosis in Cancer Cells via Dysregulation of Cell Redox Homeostasis and Inhibition of the Mevalonate Pathway

[Image: see text] A series of Ga(Q(n))(3) coordination compounds have been synthesized, where HQ(n) is 1-phenyl-3-methyl-4-RC(=O)-pyrazolo-5-one. The complexes have been characterized through analytical data, NMR and IR spectroscopy, ESI mass spectrometry, elemental analysis, X-ray crystallography,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Romani, Daphne, Marchetti, Fabio, Di Nicola, Corrado, Cuccioloni, Massimiliano, Gong, Chunmei, Eleuteri, Anna Maria, Galindo, Agustín, Fadaei-Tirani, Farzaneh, Nabissi, Massimo, Pettinari, Riccardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009752/ https://www.ncbi.nlm.nih.gov/pubmed/36802330 http://dx.doi.org/10.1021/acs.jmedchem.2c01374

Ejemplares similares

Evaluation of the antimicrobial activity of novel composite plastics containing two silver (I) additives, acyl pyrazolonate and acyl pyrazolone
por: Scuri, Stefania, et al.
Publicado: (2019)

Zinc(II) Complex with Pyrazolone-Based Hydrazones is Strongly Effective against Trypanosoma brucei Which Causes African Sleeping Sickness
por: Marchetti, Fabio, et al.
Publicado: (2022)

EVALUATION OF ANTIOXIDANT POTENTIAL OF PYRAZOLONE DERIVATIVES
por: Mariappan, G., et al.
Publicado: (2010)

An easy direct arylation of 5-pyrazolones
por: Gong, Hao, et al.
Publicado: (2013)

Enhancing the Amyloid-β Anti-Aggregation Properties of Curcumin via Arene-Ruthenium(II) Derivatization
por: Cuccioloni, Massimiliano, et al.
Publicado: (2022)

Pyrazolone ligation-mediated versatile sequential bioconjugations
por: Mailig, Melrose, et al.
Publicado: (2020)

In Vivo Trafficking of the Anticancer Drug Tris(8-Quinolinolato) Gallium (III) (KP46) by Gallium-68/67 PET/SPECT Imaging
por: Darwesh, Afnan M. F., et al.
Publicado: (2023)

Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole
por: Ariza, Adriana, et al.
Publicado: (2016)

One-pot multistep mechanochemical synthesis of fluorinated pyrazolones
por: Howard, Joseph L, et al.
Publicado: (2017)

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect
por: Zhao, Zefeng, et al.
Publicado: (2020)

Correction: Facile N-functionalization and strong magnetic communication in a diuranium(v) bis-nitride complex
por: Barluzzi, Luciano, et al.
Publicado: (2019)

Facile N-functionalization and strong magnetic communication in a diuranium(v) bis-nitride complex
por: Barluzzi, Luciano, et al.
Publicado: (2019)

Nitrogen activation and cleavage by a multimetallic uranium complex
por: Keener, Megan, et al.
Publicado: (2022)

Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Pyrazolones
por: Wen, Kangmei, et al.
Publicado: (2022)

Targeting integrin αvβ6 with gallium-68 tris (hydroxypyridinone) based PET probes
por: Floresta, Giuseppe, et al.
Publicado: (2022)

Acid-base-induced fac → mer isomerization of luminescent iridium(iii) complexes
por: Yu. Gitlina, Anastasia, et al.
Publicado: (2022)

Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome
por: Haas, Dorothea, et al.
Publicado: (2006)

SET processes in Lewis acid–base reactions: the tritylation of N-heterocyclic carbenes
por: Dong, Zhaowen, et al.
Publicado: (2020)

Diagnostic value of urinary mevalonic acid excretion in mevalonate kinase deficiency (MKD)
por: Jeyaratnam, Jerold, et al.
Publicado: (2014)

Development of Pyrazolone and Isoxazol-5-one Cambinol Analogues as Sirtuin Inhibitors
por: Mahajan, Sumit S., et al.
Publicado: (2014)

β-Enamino Esters in Heterocyclic Synthesis: Synthesis of Pyrazolone and Pyridinone Derivatives
por: Salaheldin, Abdellatif Mohamed, et al.
Publicado: (2010)

Synthesis of new pyrazolone and pyrazole-based adamantyl chalcones and antimicrobial activity
por: Al-Saheb, Rawan, et al.
Publicado: (2020)

Synthesis and Cytotoxic Evaluation of Some Substituted 5-Pyrazolones and Their Urea Derivatives
por: Gediz Erturk, Aliye, et al.
Publicado: (2020)

Spectral, thermal, antimicrobial studies for silver(I) complexes of pyrazolone derivatives
por: Mohamed, Soha F., et al.
Publicado: (2020)

Flavan‐3‐ol Microbial Metabolites Modulate Proteolysis in Neuronal Cells Reducing Amyloid‐beta (1‐42) Levels
por: Cecarini, Valentina, et al.
Publicado: (2021)

The mevalonate pathway in C. Elegans
por: Rauthan, Manish, et al.
Publicado: (2011)

Mevalonate Metabolism in Immuno-Oncology
por: Gruenbacher, Georg, et al.
Publicado: (2017)

Structural Requirements of 1-(2-Pyridinyl)-5-pyrazolones for Disproportionation of Boronic Acids
por: Cho, Joungmo, et al.
Publicado: (2021)

Synthesis of novel pyrazolone candidates with studying some biological activities and in-silico studies
por: Abdellattif, Magda H., et al.
Publicado: (2023)

Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties
por: Regnault, Romain, et al.
Publicado: (2023)

LiBF(4)‐Induced Rearrangement and Desymmetrization of a Palladium‐Ligand Assembly
por: Sudan, Sylvain, et al.
Publicado: (2022)

Mevalonate kinase somatic mosaicism and bigenic genotypes may explain heterogeneity in mevalonate kinase deficiency
por: Shinar, Y, et al.
Publicado: (2015)

Targeting Proteolysis with Cyanogenic Glycoside Amygdalin Induces Apoptosis in Breast Cancer Cells
por: Cecarini, Valentina, et al.
Publicado: (2022)

Copper and Zinc Metal–Organic Frameworks with Bipyrazole Linkers Display Strong Antibacterial Activity against Both Gram+ and Gram− Bacterial Strains
por: Xhafa, Sonila, et al.
Publicado: (2023)

Tuning the π‐Accepting Properties of Mesoionic Carbenes: A Combined Computational and Experimental Study
por: Dong, Zhaowen, et al.
Publicado: (2021)

Light‐Switchable Buffers
por: Berton, Cesare, et al.
Publicado: (2021)

A Mesoionic Diselenolene Anion and the Corresponding Radical Dianion
por: Dong, Zhaowen, et al.
Publicado: (2022)

Synthesis of Heterologous Mevalonic Acid Pathway Enzymes in Clostridium ljungdahlii for the Conversion of Fructose and of Syngas to Mevalonate and Isoprene
por: Diner, Bruce A., et al.
Publicado: (2017)

Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions
por: Ma, Ruoqun, et al.
Publicado: (2010)

Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors
por: Ramajayam, R., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_hr0h5tio0cte3sp2ljdtchga6f