Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4

[Image: see text] There is an urgent need to populate the antimalarial clinical portfolio with new candidates because of resistance against frontline antimalarials. To discover new antimalarial chemotypes, we performed a high-throughput screen of the Janssen Jumpstarter library against the Plasmodiu...

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Detalles Bibliográficos
Autores principales: Ashton, Trent D., Dans, Madeline G., Favuzza, Paola, Ngo, Anna, Lehane, Adele M., Zhang, Xinxin, Qiu, Deyun, Chandra Maity, Bikash, De, Nirupam, Schindler, Kyra A., Yeo, Tomas, Park, Heekuk, Uhlemann, Anne-Catrin, Churchyard, Alisje, Baum, Jake, Fidock, David A., Jarman, Kate E., Lowes, Kym N., Baud, Delphine, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009754/
https://www.ncbi.nlm.nih.gov/pubmed/36812492
http://dx.doi.org/10.1021/acs.jmedchem.2c02092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009754/
https://www.ncbi.nlm.nih.gov/pubmed/36812492
http://dx.doi.org/10.1021/acs.jmedchem.2c02092

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