The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection

BACKGROUND: The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change in the spike protein, associated with an increase in transmissibility. Genomes...

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Detalles Bibliográficos
Autores principales: Goldswain, Hannah, Dong, Xiaofeng, Penrice-Randal, Rebekah, Alruwaili, Muhannad, Shawli, Ghada T., Prince, Tessa, Williamson, Maia Kavanagh, Raghwani, Jayna, Randle, Nadine, Jones, Benjamin, Donovan-Banfield, I’ah, Salguero, Francisco J., Tree, Julia A., Hall, Yper, Hartley, Catherine, Erdmann, Maximilian, Bazire, James, Jearanaiwitayakul, Tuksin, Semple, Malcolm G., Openshaw, Peter J. M., Baillie, J. Kenneth, Emmett, Stevan R., Digard, Paul, Matthews, David A., Turtle, Lance, Darby, Alistair C., Davidson, Andrew D., Carroll, Miles W., Hiscox, Julian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009825/
https://www.ncbi.nlm.nih.gov/pubmed/36915185
http://dx.doi.org/10.1186/s13059-023-02881-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009825/
https://www.ncbi.nlm.nih.gov/pubmed/36915185
http://dx.doi.org/10.1186/s13059-023-02881-5

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