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The effect of dichotomization of skewed adjustment covariates in the analysis of clinical trials

Baseline imbalance in covariates associated with the primary outcome in clinical trials leads to bias in the reporting of results. Standard practice is to mitigate that bias by stratifying by those covariates in the randomization. Additionally, for continuously valued outcome variables, precision of...

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Detalles Bibliográficos
Autor principal: Herschtal, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009982/
https://www.ncbi.nlm.nih.gov/pubmed/36907867
http://dx.doi.org/10.1186/s12874-023-01878-9