SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum

Translocon clogging at the endoplasmic reticulum (ER) as a result of translation stalling triggers ribosome UFMylation, activating translocation-associated quality control (TAQC) to degrade clogged substrates. How cells sense ribosome UFMylation to initiate TAQC is unclear. We conduct a genome-wide...

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Detalles Bibliográficos
Autores principales: Wang, Lihui, Xu, Yue, Yun, Sijung, Yuan, Quan, Satpute-Krishnan, Prasanna, Ye, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010011/
https://www.ncbi.nlm.nih.gov/pubmed/36848233
http://dx.doi.org/10.1016/j.celrep.2023.112028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010011/
https://www.ncbi.nlm.nih.gov/pubmed/36848233
http://dx.doi.org/10.1016/j.celrep.2023.112028

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