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SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum
Translocon clogging at the endoplasmic reticulum (ER) as a result of translation stalling triggers ribosome UFMylation, activating translocation-associated quality control (TAQC) to degrade clogged substrates. How cells sense ribosome UFMylation to initiate TAQC is unclear. We conduct a genome-wide...
Autores principales: | Wang, Lihui, Xu, Yue, Yun, Sijung, Yuan, Quan, Satpute-Krishnan, Prasanna, Ye, Yihong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010011/ https://www.ncbi.nlm.nih.gov/pubmed/36848233 http://dx.doi.org/10.1016/j.celrep.2023.112028 |
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