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Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship

Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggressive pediatric cancer – mainly arises. Hypoxia inducible factor 1 subunit alpha (HIF-1-a) is...

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Autores principales: Ceranski, A. Katharina, Carreño-Gonzalez, Martha J., Ehlers, Anna C., Colombo, Maria Vittoria, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010019/
https://www.ncbi.nlm.nih.gov/pubmed/36915100
http://dx.doi.org/10.1186/s12943-023-01750-w
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author Ceranski, A. Katharina
Carreño-Gonzalez, Martha J.
Ehlers, Anna C.
Colombo, Maria Vittoria
Cidre-Aranaz, Florencia
Grünewald, Thomas G. P.
author_facet Ceranski, A. Katharina
Carreño-Gonzalez, Martha J.
Ehlers, Anna C.
Colombo, Maria Vittoria
Cidre-Aranaz, Florencia
Grünewald, Thomas G. P.
author_sort Ceranski, A. Katharina
collection PubMed
description Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggressive pediatric cancer – mainly arises. Hypoxia inducible factor 1 subunit alpha (HIF-1-a) is the principal molecular mediator of the hypoxic response in cancer whereas EWSR1::FLI1 constitutes the oncogenic driver of EwS. Interaction of the two proteins has been shown in EwS. Although a growing body of studies investigated hypoxia and HIFs in EwS, their precise role for EwS pathophysiology is not clarified to date. This review summarizes and structures recent findings demonstrating that hypoxia and HIFs play a role in EwS at multiple levels. We propose to view hypoxia and HIFs as independent protagonists in the story of EwS and give a perspective on their potential clinical relevance as prognostic markers and therapeutic targets in EwS treatment.
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spelling pubmed-100100192023-03-14 Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship Ceranski, A. Katharina Carreño-Gonzalez, Martha J. Ehlers, Anna C. Colombo, Maria Vittoria Cidre-Aranaz, Florencia Grünewald, Thomas G. P. Mol Cancer Review Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggressive pediatric cancer – mainly arises. Hypoxia inducible factor 1 subunit alpha (HIF-1-a) is the principal molecular mediator of the hypoxic response in cancer whereas EWSR1::FLI1 constitutes the oncogenic driver of EwS. Interaction of the two proteins has been shown in EwS. Although a growing body of studies investigated hypoxia and HIFs in EwS, their precise role for EwS pathophysiology is not clarified to date. This review summarizes and structures recent findings demonstrating that hypoxia and HIFs play a role in EwS at multiple levels. We propose to view hypoxia and HIFs as independent protagonists in the story of EwS and give a perspective on their potential clinical relevance as prognostic markers and therapeutic targets in EwS treatment. BioMed Central 2023-03-13 /pmc/articles/PMC10010019/ /pubmed/36915100 http://dx.doi.org/10.1186/s12943-023-01750-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ceranski, A. Katharina
Carreño-Gonzalez, Martha J.
Ehlers, Anna C.
Colombo, Maria Vittoria
Cidre-Aranaz, Florencia
Grünewald, Thomas G. P.
Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
title Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
title_full Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
title_fullStr Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
title_full_unstemmed Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
title_short Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
title_sort hypoxia and hifs in ewing sarcoma: new perspectives on a multi-facetted relationship
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010019/
https://www.ncbi.nlm.nih.gov/pubmed/36915100
http://dx.doi.org/10.1186/s12943-023-01750-w
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