VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer

We and others have recently shown that proteins involved in the DNA damage response (DDR) are critical for KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) cell growth in vitro. However, the CRISPR-Cas9 library that enabled us to identify these key proteins had limited representation of DDR-relat...

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Detalles Bibliográficos
Autores principales: Lee, Ye S., Klomp, Jennifer E., Stalnecker, Clint A., Goodwin, Craig M., Gao, Yanzhe, Droby, Gaith N., Vaziri, Cyrus, Bryant, Kirsten L., Der, Channing J., Cox, Adrienne D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010283/
https://www.ncbi.nlm.nih.gov/pubmed/36923647
http://dx.doi.org/10.18632/genesandcancer.231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010283/
https://www.ncbi.nlm.nih.gov/pubmed/36923647
http://dx.doi.org/10.18632/genesandcancer.231

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