Real-world Validation of TMB and Microsatellite Instability as Predictive Biomarkers of Immune Checkpoint Inhibitor Effectiveness in Advanced Gastroesophageal Cancer

Patients with advanced gastroesophageal cancer (mEG) and tumor mutational burden ≥10 mut/Mb (TMB ≥ 10) have more favorable outcomes on immune checkpoint inhibitor (ICPI) monotherapy compared with chemotherapy in subgroup analyses of randomized controlled trials. We sought to evaluate the robustness...

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Detalles Bibliográficos
Autores principales: Graf, Ryon P., Fisher, Virginia, Creeden, James, Schrock, Alexa B., Ross, Jeffrey S., Nimeiri, Halla, Oxnard, Geoffrey R., Klempner, Samuel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010289/
https://www.ncbi.nlm.nih.gov/pubmed/36922935
http://dx.doi.org/10.1158/2767-9764.CRC-22-0161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010289/
https://www.ncbi.nlm.nih.gov/pubmed/36922935
http://dx.doi.org/10.1158/2767-9764.CRC-22-0161

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