Genomic landscape of metastatic breast cancer (MBC) patients with methylthioadenosine phosphorylase (MTAP) loss

Introduction: Homozygous deletion of MTAP upregulates de novo synthesis of purine (DNSP) and increases the proliferation of neoplastic cells. This increases the sensitivity of breast cancer cells to DNSP inhibitors such as methotrexate, L-alanosine and pemetrexed. Materials and Methods: 7,301 cases...

Descripción completa

Detalles Bibliográficos
Autores principales: Bou Zerdan, Maroun, Ashok Kumar, Prashanth, Haroun, Elio, Srivastava, Nimisha, Ross, Jeffrey, Sivapiragasam, Abirami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010627/
https://www.ncbi.nlm.nih.gov/pubmed/36913304
http://dx.doi.org/10.18632/oncotarget.28376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010627/
https://www.ncbi.nlm.nih.gov/pubmed/36913304
http://dx.doi.org/10.18632/oncotarget.28376

Ejemplares similares