Cargando…

Genomic landscape of metastatic breast cancer (MBC) patients with methylthioadenosine phosphorylase (MTAP) loss

Introduction: Homozygous deletion of MTAP upregulates de novo synthesis of purine (DNSP) and increases the proliferation of neoplastic cells. This increases the sensitivity of breast cancer cells to DNSP inhibitors such as methotrexate, L-alanosine and pemetrexed. Materials and Methods: 7,301 cases...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bou Zerdan, Maroun, Ashok Kumar, Prashanth, Haroun, Elio, Srivastava, Nimisha, Ross, Jeffrey, Sivapiragasam, Abirami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010627/ https://www.ncbi.nlm.nih.gov/pubmed/36913304 http://dx.doi.org/10.18632/oncotarget.28376

Ejemplares similares

Addendum: Genomic landscape of metastatic breast cancer (MBC) patients with methylthioadenosine phosphorylase (MTAP) loss
por: Bou Zerdan, Maroun, et al.
Publicado: (2023)

Genomic landscape of non‐small‐cell lung cancer with methylthioadenosine phosphorylase (MTAP) deficiency
por: Ashok Kumar, Prashanth, et al.
Publicado: (2022)

Deletion of Dinucleotide Repeat (Δ14 Allele) in the Methylthioadenosine Phosphorylase (MTAP) Promoter and the Allelotype of MTAP Promoter in the Japanese Population
por: Kadariya, Yuwaraj, et al.
Publicado: (2002)

Loss of 5′-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness
por: de Menezes, Weder Pereira, et al.
Publicado: (2020)

Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination
por: Tedeschi, Philip M., et al.
Publicado: (2015)

Molecular Targets in Salivary Gland Cancers: A Comprehensive Genomic Analysis of 118 Mucoepidermoid Carcinoma Tumors
por: Bou Zerdan, Maroun, et al.
Publicado: (2023)

Radiation Recall Dermatitis Following Treatment With Pembrolizumab: A Case Report and Review of the Literature
por: Sandhu, Michael, et al.
Publicado: (2023)

Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
por: Barekatain, Yasaman, et al.
Publicado: (2021)

The essential role of methylthioadenosine phosphorylase in prostate cancer
por: Bistulfi, Gaia, et al.
Publicado: (2016)

Expression and Function of Methylthioadenosine Phosphorylase in Chronic Liver Disease
por: Czech, Barbara, et al.
Publicado: (2013)

Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma
por: He, Hong-Lin, et al.
Publicado: (2015)

Methylthioadenosine phosphorylase deficiency in tumors: A compelling therapeutic target
por: Fan, Na, et al.
Publicado: (2023)

Selective Killing of Tumors Deficient in Methylthioadenosine Phosphorylase: A Novel Strategy
por: Lubin, Martin, et al.
Publicado: (2009)

Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5’-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway
por: Torini, Juliana Roberta, et al.
Publicado: (2016)

Correction: Selective Killing of Tumors Deficient in Methylthioadenosine Phosphorylase: A Novel Strategy
por: Lubin, Martin, et al.
Publicado: (2010)

Landscape of HER2-low metastatic breast cancer (MBC): results from the Austrian AGMT_MBC-Registry
por: Gampenrieder, Simon Peter, et al.
Publicado: (2021)

Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma
por: Limm, Katharina, et al.
Publicado: (2016)

A Study on the Interaction of Rhodamine B with Methylthioadenosine Phosphorylase Protein Sourced from an Antarctic Soil Metagenomic Library
por: Bartasun, Paulina, et al.
Publicado: (2013)

Leishmania infantum 5’-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target
por: Abid, Hela, et al.
Publicado: (2017)

The Lung Microbiota and Lung Cancer: A Growing Relationship
por: Bou Zerdan, Maroun, et al.
Publicado: (2022)

Genomic landscape of clinically advanced KRAS wild-type pancreatic ductal adenocarcinoma
por: Ashok Kumar, Prashanth, et al.
Publicado: (2023)

Primary Mucinous Adenocarcinoma of the Upper Eyelid in an African American Female: A Rare Clinical Entity. A Case Report and Literature Review
por: Ashok Kumar, Prashanth, et al.
Publicado: (2019)

Liquid biopsies and minimal residual disease in lymphoid malignancies
por: Bou Zerdan, Maroun, et al.
Publicado: (2023)

Methylthioadenosine Suppresses Salmonella Virulence
por: Bourgeois, Jeffrey S., et al.
Publicado: (2018)

Associated factors and outcomes of delaying adjuvant chemotherapy in breast cancer by biologic subtypes: a National Cancer Database study
por: Ashok Kumar, Prashanth, et al.
Publicado: (2021)

Current Trends in the Management of Epithelial Lacrimal Gland Tumors: A Retrospective National Cancer Database Analysis
por: Ashok Kumar, Prashanth, et al.
Publicado: (2022)

Ductal Adenocarcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland: a Rare and Morbid Malignancy
por: Ashok Kumar, Prashanth, et al.
Publicado: (2020)

Advancements in the Treatment of Metastatic Breast Cancer (MBC): The Role of Ixabepilone
por: Cristofanilli, Massimo
Publicado: (2012)

MTAP loss: a possible therapeutic approach for glioblastoma
por: Patro, C. Pawan K., et al.
Publicado: (2022)

Catalytic Site Cooperativity in Dimeric Methylthioadenosine Nucleosidase
por: Wang, Shanzhi, et al.
Publicado: (2014)

Insights of Medical Students and Graduates Toward Electronic Learning During the COVID-19 Pandemic in Lebanon: A National Cross-Sectional Study
por: Bou Zerdan, Maroun, et al.
Publicado: (2023)

Oligodendroglioma: A Review of Management and Pathways
por: Bou Zerdan, Maroun, et al.
Publicado: (2021)

MTAP: The Motif Tool Assessment Platform
por: Quest, Daniel, et al.
Publicado: (2008)

Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer
por: Sivapiragasam, Abirami, et al.
Publicado: (2020)

Deletions of CDKN2A and MTAP Detected by Copy-Number Variation Array Are Associated with Loss of p16 and MTAP Protein in Pleural Mesothelioma
por: Vrugt, Bart, et al.
Publicado: (2023)

Differential Neuroprotective Effects of 5′-Deoxy-5′-Methylthioadenosine
por: Moreno, Beatriz, et al.
Publicado: (2014)

5'-Methylthioadenosine and Cancer: old molecules, new understanding
por: Li, Yaofeng, et al.
Publicado: (2019)

Use of the metastatic breast cancer progression (MBC-P) questionnaire to assess the value of progression-free survival for women with metastatic breast cancer
por: Hurvitz, Sara A., et al.
Publicado: (2013)

The Impacts of Inclusion in Clinical Trials on Outcomes among Patients with Metastatic Breast Cancer (MBC)
por: Lee, Ji Yun, et al.
Publicado: (2016)

HGG-02. METABOLIC TARGETING OF HIGH-GRADE GLIOMAS WITH MTAP LOSS
por: Subramaniam, Bavani, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5lmr153n69mkpvdq1k65r910jl