A Pharmacokinetic, Safety, and Tolerability Trial of Palovarotene in Healthy Japanese and Non-Japanese Participants

BACKGROUND AND OBJECTIVE: Palovarotene is an oral, selective retinoic acid receptor gamma agonist under investigation for fibrodysplasia ossificans progressiva (FOP). Palovarotene is primarily metabolized by cytochrome P450 (CYP) 3A4. Differences in CYP-mediated metabolism of CYP substrates have bee...

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Detalles Bibliográficos
Autores principales: Dube, Louise, Haga, Nobuhiko, Grogan, Donna, Ogier, Julien, Le Quan Sang, Kim-Hanh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011291/
https://www.ncbi.nlm.nih.gov/pubmed/36802022
http://dx.doi.org/10.1007/s13318-023-00815-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011291/
https://www.ncbi.nlm.nih.gov/pubmed/36802022
http://dx.doi.org/10.1007/s13318-023-00815-x

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