Transcranial focused ultrasound-mediated unbinding of phenytoin from plasma proteins for suppression of chronic temporal lobe epilepsy in a rodent model

The efficacy of many anti-epileptic drugs, including phenytoin (PHT), is reduced by plasma protein binding (PPB) that sequesters therapeutically active drug molecules within the bloodstream. An increase in systemic dose elevates the risk of drug side effects, which demands an alternative technique t...

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Detalles Bibliográficos
Autores principales: Kim, Evgenii, Kim, Hyun-Chul, Van Reet, Jared, Böhlke, Mark, Yoo, Seung-Schik, Lee, Wonhye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011522/
https://www.ncbi.nlm.nih.gov/pubmed/36914775
http://dx.doi.org/10.1038/s41598-023-31383-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011522/
https://www.ncbi.nlm.nih.gov/pubmed/36914775
http://dx.doi.org/10.1038/s41598-023-31383-4

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