Cargando…

Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization

Atherosclerotic plaque rupture leading to myocardial infarction is a major global health burden. Applying the tandem stenosis (TS) mouse model, which distinctively exhibits the characteristics of human plaque instability/rupture, we use quantitative proteomics to understand and directly compare unst...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yung-Chih, Smith, Meaghan, Ying, Ya-Lan, Makridakis, Manousos, Noonan, Jonathan, Kanellakis, Peter, Rai, Alin, Salim, Agus, Murphy, Andrew, Bobik, Alex, Vlahou, Antonia, Greening, David W., Peter, Karlheinz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011552/ https://www.ncbi.nlm.nih.gov/pubmed/36914713 http://dx.doi.org/10.1038/s42003-023-04641-4

Ejemplares similares

Pharmacological Inhibition of Factor XIIa Attenuates Abdominal Aortic Aneurysm, Reduces Atherosclerosis, and Stabilizes Atherosclerotic Plaques
por: Searle, Amy K., et al.
Publicado: (2021)

Anti‐TIM‐1 Monoclonal Antibody (RMT1‐10) Attenuates Atherosclerosis By Expanding IgM‐producing B1a Cells
por: Hosseini, Hamid, et al.
Publicado: (2018)

B Cell and CD4 T Cell Interactions Promote Development of Atherosclerosis
por: Tay, Christopher, et al.
Publicado: (2020)

The Search for Associations of Serum Proteins with the Presence of Unstable Atherosclerotic Plaque in Coronary Atherosclerosis
por: Stakhneva, Ekaterina Mikhailovna, et al.
Publicado: (2022)

Crosstalk between cytotoxic CD8+ T cells and stressed cardiomyocytes triggers development of interstitial cardiac fibrosis in hypertensive mouse hearts
por: Brassington, Kurt, et al.
Publicado: (2022)

In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome
por: Gourdomichali, Olga, et al.
Publicado: (2022)

A Proteomic Approach to Study the Biological Role of Hepatitis C Virus Protein Core+1/ARFP
por: Vrazas, Vasileios, et al.
Publicado: (2022)

Glycosylation Analysis of Urinary Peptidome Highlights IGF2 Glycopeptides in Association with CKD
por: Lohia, Sonnal, et al.
Publicado: (2023)

BAFF Receptor mAb Treatment Ameliorates Development and Progression of Atherosclerosis in Hyperlipidemic ApoE(−/−) Mice
por: Kyaw, Tin, et al.
Publicado: (2013)

Cathepsin L in unstable plaques
por: Bashir, Ayisha Z.
Publicado: (2020)

Molecular Changes in Tissue Proteome during Prostate Cancer Development: Proof-of-Principle Investigation
por: Latosinska, Agnieszka, et al.
Publicado: (2020)

APEX2-Mediated Proximity Labeling Resolves the DDIT4-Interacting Proteome
por: Naki, Marianna, et al.
Publicado: (2022)

Depletion of B2 but Not B1a B Cells in BAFF Receptor-Deficient ApoE(−/−) Mice Attenuates Atherosclerosis by Potently Ameliorating Arterial Inflammation
por: Kyaw, Tin, et al.
Publicado: (2012)

Highly Sensitive Detection of Minimal Cardiac Ischemia using Positron Emission Tomography Imaging of Activated Platelets
por: Ziegler, Melanie, et al.
Publicado: (2016)

Raised Soluble P-Selectin Moderately Accelerates Atherosclerotic Plaque Progression
por: Woollard, Kevin J., et al.
Publicado: (2014)

Role of sirtuins in attenuating plaque vulnerability in atherosclerosis
por: Velpuri, Prathosh, et al.
Publicado: (2023)

Functional secretome analysis reveals Annexin-A1 as important paracrine factor derived from fetal mesenchymal stem cells in hepatic regeneration
por: Zagoura, Dimitra, et al.
Publicado: (2019)

The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I
por: Mavridis, George, et al.
Publicado: (2021)

Toll‐Like Receptor (TLR)4 and MyD88 are Essential for Atheroprotection by Peritoneal B1a B Cells
por: Hosseini, Hamid, et al.
Publicado: (2016)

In vitro and in vivo properties of distinct populations of amniotic fluid mesenchymal progenitor cells
por: Roubelakis, Maria G, et al.
Publicado: (2011)

Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease
por: Lygirou, Vasiliki, et al.
Publicado: (2018)

Proteomic Analysis of Mouse Kidney Tissue Associates Peroxisomal Dysfunction with Early Diabetic Kidney Disease
por: Tserga, Aggeliki, et al.
Publicado: (2022)

New methods to image unstable atherosclerotic plaques
por: Andrews, Jack P.M., et al.
Publicado: (2018)

Molecular imaging of MMP activity discriminates unstable from stable plaque phenotypes in shear-stress induced murine atherosclerosis
por: Seifert, Robert, et al.
Publicado: (2018)

Multiplexed MRM-based protein quantification of putative prognostic biomarkers for chronic kidney disease progression in plasma
por: Makridakis, Manousos, et al.
Publicado: (2020)

Integrative analysis of extracellular and intracellular bladder cancer cell line proteome with transcriptome: improving coverage and validity of –omics findings
por: Latosinska, Agnieszka, et al.
Publicado: (2016)

Insights into Biomechanical and Proteomic Characteristics of Small Diameter Vascular Grafts Utilizing the Human Umbilical Artery
por: Mallis, Panagiotis, et al.
Publicado: (2020)

Short Term Results of Fibrin Gel Obtained from Cord Blood Units: A Preliminary in Vitro Study
por: Mallis, Panagiotis, et al.
Publicado: (2019)

Utility of mass spectrometry for the diagnosis of the unstable coronary plaque
por: Jacob, Shana S, et al.
Publicado: (2015)

Endometrial small extracellular vesicles regulate human trophectodermal cell invasion by reprogramming the phosphoproteome landscape
por: Fatmous, Monique, et al.
Publicado: (2022)

Cervical Cancer Cell Line Secretome Highlights the Roles of Transforming Growth Factor-Beta-Induced Protein ig-h3, Peroxiredoxin-2, and NRF2 on Cervical Carcinogenesis
por: Kontostathi, Georgia, et al.
Publicado: (2017)

Gene Expression Monotonicity across Bladder Cancer Stages Informs on the Molecular Pathogenesis and Identifies a Prognostic Eight-Gene Signature
por: Stroggilos, Rafael, et al.
Publicado: (2022)

The Relation between Atherosclerosis Plaque Composition and Plaque Rupture
por: Babaniamansour, Parto, et al.
Publicado: (2020)

Increased expression of endothelial lipase in symptomatic and unstable carotid plaques
por: Trbušić, Matias, et al.
Publicado: (2011)

Imaging of the unstable plaque: how far have we got?
por: Matter, Christian M., et al.
Publicado: (2009)

Aspirin inhibits human telomerase activation in unstable carotid plaques
por: LI, FANGMING, et al.
Publicado: (2013)

Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque
por: Kowara, Michal, et al.
Publicado: (2021)

Contribution of FBLN5 to Unstable Plaques in Carotid Atherosclerosis via mir128 and mir532–3p Based on Bioinformatics Prediction and Validation
por: Zheng, Lin, et al.
Publicado: (2022)

Non-Coding RNAs in Regulating Plaque Progression and Remodeling of Extracellular Matrix in Atherosclerosis
por: Singh, Drishtant, et al.
Publicado: (2022)

Comparative Analysis of Label-Free and 8-Plex iTRAQ Approach for Quantitative Tissue Proteomic Analysis
por: Latosinska, Agnieszka, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_e0a98ql44svdpq8u22ghhurgvu