SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice

Inhibition of AMPK is tightly associated with metabolic perturbations upon over nutrition, yet the molecular mechanisms underlying are not clear. Here, we demonstrate the serine/threonine-protein phosphatase 6 regulatory subunit 3, SAPS3, is a negative regulator of AMPK. SAPS3 is induced under high...

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Detalles Bibliográficos
Autores principales: Yang, Ying, Reid, Michael A., Hanse, Eric A., Li, Haiqing, Li, Yuanding, Ruiz, Bryan I., Fan, Qi, Kong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011557/
https://www.ncbi.nlm.nih.gov/pubmed/36914647
http://dx.doi.org/10.1038/s41467-023-36809-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011557/
https://www.ncbi.nlm.nih.gov/pubmed/36914647
http://dx.doi.org/10.1038/s41467-023-36809-1

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