Conformational transitions and allosteric modulation in a heteromeric glycine receptor

Glycine Receptors (GlyRs) provide inhibitory neuronal input in the spinal cord and brainstem, which is critical for muscle coordination and sensory perception. Synaptic GlyRs are a heteromeric assembly of α and β subunits. Here we present cryo-EM structures of full-length zebrafish α1β(B)GlyR in the...

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Detalles Bibliográficos
Autores principales: Gibbs, Eric, Klemm, Emily, Seiferth, David, Kumar, Arvind, Ilca, Serban L., Biggin, Philip C., Chakrapani, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011588/
https://www.ncbi.nlm.nih.gov/pubmed/36914669
http://dx.doi.org/10.1038/s41467-023-37106-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011588/
https://www.ncbi.nlm.nih.gov/pubmed/36914669
http://dx.doi.org/10.1038/s41467-023-37106-7

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