Design and synthesis of novel cytotoxic fluoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis

To exploit the advantageous properties of approved drugs to hasten anticancer drug discovery, we designed and synthesized a series of fluoroquinolone (FQ) analogs via functionalization of the acid hydrazides of moxifloxacin, ofloxacin, and ciprofloxacin. Under the NCI-60 Human Tumor Cell Line Screen...

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Detalles Bibliográficos
Autores principales: Elanany, Mohamed A., Osman, Essam Eldin A., Gedawy, Ehab Mohamed, Abou-Seri, Sahar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011602/
https://www.ncbi.nlm.nih.gov/pubmed/36914702
http://dx.doi.org/10.1038/s41598-023-30885-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011602/
https://www.ncbi.nlm.nih.gov/pubmed/36914702
http://dx.doi.org/10.1038/s41598-023-30885-5

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