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Cholinergic deficits selectively boost cortical intratelencephalic control of striatum in male Huntington’s disease model mice
Huntington’s disease (HD) is a progressive, neurodegenerative disease caused by a CAG triplet expansion in huntingtin. Although corticostriatal dysfunction has long been implicated in HD, the determinants and pathway specificity of this pathophysiology are not fully understood. Here, using a male zQ...
Autores principales: | Pancani, Tristano, Day, Michelle, Tkatch, Tatiana, Wokosin, David L., González-Rodríguez, Patricia, Kondapalli, Jyothisri, Xie, Zhong, Chen, Yu, Beaumont, Vahri, Surmeier, D. James |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011605/ https://www.ncbi.nlm.nih.gov/pubmed/36914640 http://dx.doi.org/10.1038/s41467-023-36556-3 |
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