A mechanism of salt bridge–mediated resistance to FtsZ inhibitor PC190723 revealed by a cell-based screen

Bacterial cell division proteins, especially the tubulin homologue FtsZ, have emerged as strong targets for developing new antibiotics. Here, we have utilized the fission yeast heterologous expression system to develop a cell-based assay to screen for small molecules that directly and specifically t...

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Detalles Bibliográficos
Autores principales: Sharma, Ajay Kumar, Poddar, Sakshi Mahesh, Chakraborty, Joyeeta, Nayak, Bhagyashri Soumya, Kalathil, Srilakshmi, Mitra, Nivedita, Gayathri, Pananghat, Srinivasan, Ramanujam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011733/
https://www.ncbi.nlm.nih.gov/pubmed/36652338
http://dx.doi.org/10.1091/mbc.E22-12-0538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011733/
https://www.ncbi.nlm.nih.gov/pubmed/36652338
http://dx.doi.org/10.1091/mbc.E22-12-0538

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