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The β-latch structural element of the SufS cysteine desulfurase mediates active site accessibility and SufE transpersulfurase positioning

Under oxidative stress and iron starvation conditions, Escherichia coli uses the Suf pathway to assemble iron-sulfur clusters. The Suf pathway mobilizes sulfur via SufS, a type II cysteine desulfurase. SufS is a pyridoxal-5′-phosphate–dependent enzyme that uses cysteine to generate alanine and an ac...

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Detalles Bibliográficos
Autores principales: Gogar, Rajleen K., Carroll, Franki, Conte, Juliana V., Nasef, Mohamed, Dunkle, Jack A., Frantom, Patrick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011822/
https://www.ncbi.nlm.nih.gov/pubmed/36736428
http://dx.doi.org/10.1016/j.jbc.2023.102966