Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation

Glutamine synthetase (GS), which catalyzes the ATP-dependent synthesis of L-glutamine from L-glutamate and ammonia, is a ubiquitous and conserved enzyme that plays a pivotal role in nitrogen metabolism across all life domains. In vertebrates, GS is highly expressed in astrocytes, where its activity...

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Detalles Bibliográficos
Autores principales: Campolo, Nicolás, Mastrogiovanni, Mauricio, Mariotti, Michele, Issoglio, Federico M., Estrin, Darío, Hägglund, Per, Grune, Tilman, Davies, Michael J., Bartesaghi, Silvina, Radi, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011836/
https://www.ncbi.nlm.nih.gov/pubmed/36702251
http://dx.doi.org/10.1016/j.jbc.2023.102941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011836/
https://www.ncbi.nlm.nih.gov/pubmed/36702251
http://dx.doi.org/10.1016/j.jbc.2023.102941

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