Synthesis, α-mannosidase inhibition studies and molecular modeling of 1,4-imino-ᴅ-lyxitols and their C-5-altered N-arylalkyl derivatives

A synthesis of 1,4-imino-ᴅ-lyxitols and their N-arylalkyl derivatives altered at C-5 is reported. Their inhibitory activity and selectivity toward four GH38 α-mannosidases (two Golgi types: GMIIb from Drosophila melanogaster and AMAN-2 from Caenorhabditis elegans, and two lysosomal types: LManII fro...

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Detalles Bibliográficos
Autores principales: Kalník, Martin, Šesták, Sergej, Kóňa, Juraj, Bella, Maroš, Poláková, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2023
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012049/
https://www.ncbi.nlm.nih.gov/pubmed/36925565
http://dx.doi.org/10.3762/bjoc.19.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012049/
https://www.ncbi.nlm.nih.gov/pubmed/36925565
http://dx.doi.org/10.3762/bjoc.19.24

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