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Molecular Signatures of the Eagle Effect Induced by the Artificial Siderophore Conjugate LP-600 in E. coli

[Image: see text] Achieving cellular uptake is a central challenge for novel antibiotics targeting Gram-negative bacterial pathogens. One strategy is to hijack the bacterial iron transport system by siderophore-antibiotic conjugates that are actively imported into the cell. This was realized with th...

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Detalles Bibliográficos
Autores principales: Lai, Yi-Hui, Franke, Raimo, Pinkert, Lukas, Overwin, Heike, Brönstrup, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012262/
https://www.ncbi.nlm.nih.gov/pubmed/36763039
http://dx.doi.org/10.1021/acsinfecdis.2c00567