Cargando…
Molecular Signatures of the Eagle Effect Induced by the Artificial Siderophore Conjugate LP-600 in E. coli
[Image: see text] Achieving cellular uptake is a central challenge for novel antibiotics targeting Gram-negative bacterial pathogens. One strategy is to hijack the bacterial iron transport system by siderophore-antibiotic conjugates that are actively imported into the cell. This was realized with th...
Autores principales: | Lai, Yi-Hui, Franke, Raimo, Pinkert, Lukas, Overwin, Heike, Brönstrup, Mark |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012262/ https://www.ncbi.nlm.nih.gov/pubmed/36763039 http://dx.doi.org/10.1021/acsinfecdis.2c00567 |
Ejemplares similares
-
Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa
por: Franke, Raimo, et al.
Publicado: (2021) -
Siderophore conjugation with cleavable linkers boosts the potency of RNA polymerase inhibitors against multidrug-resistant E. coli
por: Peukert, Carsten, et al.
Publicado: (2023) -
Enzyme‐Activated, Chemiluminescent Siderophore‐Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial Pathogens
por: Peukert, Carsten, et al.
Publicado: (2022) -
The design and synthesis of an antibacterial phenothiazine–siderophore conjugate
por: Tarapdar, Abed, et al.
Publicado: (2018) -
Siderophore–Antibiotic Conjugate Design: New Drugs for Bad Bugs?
por: Negash, Kokob H., et al.
Publicado: (2019)