Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b

BACKGROUND: A key histopathological hallmark of Alzheimer’s disease (AD) is the presence of neurofibrillary tangles of aggregated microtubule-associated protein tau in neurons. Anle138b is a small molecule which has previously shown efficacy in mice in reducing tau aggregates and rescuing AD disease...

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Detalles Bibliográficos
Autores principales: Hosseini-Gerami, Layla, Ficulle, Elena, Humphryes-Kirilov, Neil, Airey, David C., Scherschel, James, Kananathan, Sarubini, Eastwood, Brian J., Bose, Suchira, Collier, David A., Laing, Emma, Evans, David, Broughton, Howard, Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012450/
https://www.ncbi.nlm.nih.gov/pubmed/36918909
http://dx.doi.org/10.1186/s13195-023-01182-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012450/
https://www.ncbi.nlm.nih.gov/pubmed/36918909
http://dx.doi.org/10.1186/s13195-023-01182-0

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