Cargando…

Design, biological evaluation, and molecular modelling insights of cupressic acid derivatives as promising anti-inflammatory agents

The major labdanes in the oleogum resin of Araucaria heterophylla (Salisb.) Franco, 13-epi-cupressic acid (1) and acetyl-13-epi-cupressic acid (2) were used to prepare seven new (3–9), along with one known (10) derivatives. RAW264.7 cells were used to evaluate the anti-inflammatory activity of the d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soliman, Amal F., Elimam, Diaaeldin M., El-Senduny, Fardous F., Alossaimi, Manal A., Alamri, Mubarak, Abdel Bar, Fatma M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013213/ https://www.ncbi.nlm.nih.gov/pubmed/36912259 http://dx.doi.org/10.1080/14756366.2023.2187327

Ejemplares similares

Natural inspired piperine-based ureas and amides as novel antitumor agents towards breast cancer
por: Elimam, Diaaeldin M., et al.
Publicado: (2021)

Pelargonium sidoides Root Extract: Simultaneous HPLC Separation, Determination, and Validation of Selected Biomolecules and Evaluation of SARS-CoV-2 Inhibitory Activity
por: Alossaimi, Manal A., et al.
Publicado: (2022)

Structure-based virtual screening and molecular dynamics of phytochemicals derived from Saudi medicinal plants to identify potential COVID-19 therapeutics
por: Alamri, Mubarak A., et al.
Publicado: (2020)

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Mesenchymal stem cells alleviate hydrochloric acid-induced lung injury through suppression of inflammation, oxidative stress and apoptosis in comparison to moxifloxacin and sildenafil
por: El-Metwaly, Shimaa, et al.
Publicado: (2019)

Design, Synthesis, ADME, and Anticancer Studies of Newer N-Aryl-5-(3,4,5-Trifluorophenyl)-1,3,4-Oxadiazol-2-Amines: An Insight into Experimental and Theoretical Investigations
por: Agarwal, Mohit, et al.
Publicado: (2023)

Anti-Quorum Sensing and Anti-Biofilm Activity of Pelargonium × hortorum Root Extract against Pseudomonas aeruginosa: Combinatorial Effect of Catechin and Gallic Acid
por: Abdel Bar, Fatma M., et al.
Publicado: (2022)

Design, Synthesis, and Biological Evaluation of a Novel VEGFR-2 Inhibitor Based on a 1,2,5-Oxadiazole-2-Oxide Scaffold with MAPK Signaling Pathway Inhibition
por: Mahnashi, Mater H., et al.
Publicado: (2022)

In Vitro and In Silico Investigation of Polyacetylenes from Launaea capitata (Spreng.) Dandy as Potential COX-2, 5-LOX, and BchE Inhibitors
por: Abdel Bar, Fatma M., et al.
Publicado: (2023)

Synthesis and Anticancer Evaluation of 4-Chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol Analogues: An Insight into Experimental and Theoretical Studies
por: Afzal, Obaid, et al.
Publicado: (2023)

Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1
por: Barakat, Assem, et al.
Publicado: (2018)

Resveratrol-Loaded Chia Seed Oil-Based Nanogel as an Anti-Inflammatory in Adjuvant-Induced Arthritis
por: Afzal, Obaid, et al.
Publicado: (2023)

Molecular and Structural Analysis of Specific Mutations from Saudi Isolates of SARS-CoV-2 RNA-Dependent RNA Polymerase and their Implications on Protein Structure and Drug–Protein Binding
por: Alamri, Mubarak A., et al.
Publicado: (2022)

Down regulation of fatty acid synthase via inhibition of PI3K/AKT/mTOR in ovarian cancer cell line by novel organoselenium pseudopeptide
por: El-Saudi, Abeer M., et al.
Publicado: (2022)

Promising Antidiabetic and Antimicrobial Agents Based on Fused Pyrimidine Derivatives: Molecular Modeling and Biological Evaluation with Histopathological Effect
por: Bassyouni, Fatma, et al.
Publicado: (2021)

Anticancer Indole-Based Chalcones: A Structural and Theoretical Analysis
por: Badria, Farid A., et al.
Publicado: (2019)

Natural Formulations: Novel Viewpoint for Scleroderma Adjunct Treatment
por: Assar, Shirin, et al.
Publicado: (2021)

Synthesis, Anticancer Screening of Some Novel Trimethoxy Quinazolines and VEGFR2, EGFR Tyrosine Kinase Inhibitors Assay; Molecular Docking Studies
por: Altamimi, Abdulmalik S., et al.
Publicado: (2021)

On the Neuroprotective Effects of Naringenin: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective
por: Nouri, Zeinab, et al.
Publicado: (2019)

Streptomyces as a promising biological control agents for plant pathogens
por: Khan, Shaista, et al.
Publicado: (2023)

Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases
por: Momtaz, Saeideh, et al.
Publicado: (2020)

Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets
por: Chopra, Hitesh, et al.
Publicado: (2021)

Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight
por: Sharma, Divya, et al.
Publicado: (2022)

Novel 2-Sulfanylquinazolin-4(3H)-one Derivatives as Multi-Kinase Inhibitors and Apoptosis Inducers: A Synthesis, Biological Evaluation, and Molecular Docking Study
por: Altharawi, Ali, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents
por: Di Filippo, Ester Sara, et al.
Publicado: (2020)

A new promising biological agent for refractory lupus nephritis: Telitacicept
por: Liu, Shuangyan, et al.
Publicado: (2023)

Encapsulated polycaprolactone with triazole derivatives and selenium nanoparticles as promising antiproliferative and anticancer agents
por: Abdelhamid, Ahmed E., et al.
Publicado: (2023)

Novel and Potential Small Molecule Scaffolds as DYRK1A Inhibitors by Integrated Molecular Docking-Based Virtual Screening and Dynamics Simulation Study
por: Shahroz, Mir Mohammad, et al.
Publicado: (2022)

MicroRNAs: New Insights into Chronic Childhood Diseases
por: Omran, Ahmed, et al.
Publicado: (2013)

Synthesis of Pyridine-Dicarboxamide-Cyclohexanone Derivatives: Anticancer and α-Glucosidase Inhibitory Activities and In Silico Study
por: Al-Majid, Abdullah Mohammed, et al.
Publicado: (2019)

Evaluation of synthesized biosurfactants as promising corrosion inhibitors and alternative antibacterial and antidermatophytes agents
por: Fawzy, Ahmed, et al.
Publicado: (2023)

Computational and Biological Evaluation of β-Adrenoreceptor Blockers as Promising Bacterial Anti-Virulence Agents
por: Almalki, Ahmad J., et al.
Publicado: (2022)

Nigella sativa oil: A promising prospective antifungal agent in the manufacture of low-salt soft cheese
por: Abdel-Latif, Eman F., et al.
Publicado: (2021)

Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective
por: Farzaei, Mohammad Hosein, et al.
Publicado: (2018)

Zinc oxide nanoparticles and spironolactone-enhanced Nrf2/HO-1 pathway and inhibited Wnt/β-catenin pathway in adenine-induced nephrotoxicity in rats
por: Awadalla, Amira, et al.
Publicado: (2022)

Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
por: Zhou, Chenhui, et al.
Publicado: (2023)

Promising Chemotherapy for Malignant Pediatric Brain Tumor in Recent Biological Insights
por: Zhou, Qian, et al.
Publicado: (2022)

Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms
por: Eldehna, Wagdy M., et al.
Publicado: (2022)

An updated investigation on the dromedary camel cerebellum (Camelus dromedarius) with special insight into the distribution of calcium-binding proteins
por: Attaai, Abdelraheim H., et al.
Publicado: (2020)

An Insight into Symmetrical Cyanine Dyes as Promising Selective Antiproliferative Agents in Caco-2 Colorectal Cancer Cells
por: Serrano, João L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_49d0ucrt6g1221bgef603quqf8