Ubiquitin-modifying enzymes in Huntington’s disease

Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the N-terminus of the HTT gene. The CAG repeat expansion translates into a polyglutamine expansion in the mutant HTT (mHTT) protein, resulting in intracellular aggregation and neurotoxicity. Lowering the mH...

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Detalles Bibliográficos
Autores principales: Sap, Karen A., Geijtenbeek, Karlijne W., Schipper-Krom, Sabine, Guler, Arzu Tugce, Reits, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013475/
https://www.ncbi.nlm.nih.gov/pubmed/36926679
http://dx.doi.org/10.3389/fmolb.2023.1107323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013475/
https://www.ncbi.nlm.nih.gov/pubmed/36926679
http://dx.doi.org/10.3389/fmolb.2023.1107323

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