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Ubiquitin-modifying enzymes in Huntington’s disease

Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the N-terminus of the HTT gene. The CAG repeat expansion translates into a polyglutamine expansion in the mutant HTT (mHTT) protein, resulting in intracellular aggregation and neurotoxicity. Lowering the mH...

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Detalles Bibliográficos
Autores principales:	Sap, Karen A., Geijtenbeek, Karlijne W., Schipper-Krom, Sabine, Guler, Arzu Tugce, Reits, Eric A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013475/ https://www.ncbi.nlm.nih.gov/pubmed/36926679 http://dx.doi.org/10.3389/fmolb.2023.1107323

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