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Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Ligand-binding promiscuity in detoxification systems protects the body from toxicological harm but is a roadblock to drug development due to the difficulty in optimizing small molecules to both retain target potency and avoid metabolic events. Immense effort is invested in evaluating metabolism of m...

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Detalles Bibliográficos
Autores principales: Lin, Wenwei, Huber, Andrew D., Poudel, Shyaron, Li, Yongtao, Seetharaman, Jayaraman, Miller, Darcie J., Chen, Taosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013835/
https://www.ncbi.nlm.nih.gov/pubmed/36848571
http://dx.doi.org/10.1073/pnas.2217804120