Cargando…

Neuron-specific transcriptomic signatures indicate neuroinflammation and altered neuronal activity in ASD temporal cortex

Autism spectrum disorder (ASD) is a highly heterogeneous disorder, yet transcriptomic profiling of bulk brain tissue has identified substantial convergence among dysregulated genes and pathways in ASD. However, this approach lacks cell-specific resolution. We performed comprehensive transcriptomic a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Pan, Omanska, Alicja, Ander, Bradley P., Gandal, Michael J., Stamova, Boryana, Schumann, Cynthia M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013873/ https://www.ncbi.nlm.nih.gov/pubmed/36862688 http://dx.doi.org/10.1073/pnas.2206758120

Ejemplares similares

Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain
por: Schumann, Cynthia M., et al.
Publicado: (2017)

Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders
por: Ander, Bradley P., et al.
Publicado: (2015)

Specific Regional and Age-Related Small Noncoding RNA Expression Patterns Within Superior Temporal Gyrus of Typical Human Brains Are Less Distinct in Autism Brains
por: Stamova, Boryana, et al.
Publicado: (2015)

Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer’s Disease Brain: A Review
por: Zhan, Xinhua, et al.
Publicado: (2018)

Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD
por: Gandal, Michael J., et al.
Publicado: (2022)

Atypical functional connectivity of temporal cortex with precuneus and visual regions may be an early-age signature of ASD
por: Xiao, Yaqiong, et al.
Publicado: (2023)

Transcriptomic Analysis of Starch Biosynthesis in the Developing Grain of Hexaploid Wheat
por: Stamova, Boryana S., et al.
Publicado: (2009)

microRNA Expression in Peripheral Blood Cells following Acute Ischemic Stroke and Their Predicted Gene Targets
por: Jickling, Glen C., et al.
Publicado: (2014)

Monocyte, neutrophil, and whole blood transcriptome dynamics following ischemic stroke
por: Carmona-Mora, Paulina, et al.
Publicado: (2023)

Subarachnoid hemorrhage triggers neuroinflammation of the entire cerebral cortex, leading to neuronal cell death
por: Yamada, Hiroki, et al.
Publicado: (2022)

Neuroinflammation in motor neuron disease
por: Komine, Okiru, et al.
Publicado: (2015)

Smoking affects gene expression in blood of patients with ischemic stroke
por: Cheng, Xiyuan, et al.
Publicado: (2019)

Molecular Profiles of Pyramidal Neurons in the Superior Temporal Cortex in Schizophrenia
por: Pietersen, Charmaine Y., et al.
Publicado: (2014)

Gene expression in blood is associated with risperidone response in children with autism spectrum disorders
por: Lit, Lisa, et al.
Publicado: (2011)

mRNA Expression Profiles from Whole Blood Associated with Vasospasm in Patients with Subarachnoid Hemorrhage
por: Xu, Huichun, et al.
Publicado: (2019)

Color Selectivity of Neurons in the Posterior Inferior Temporal Cortex of the Macaque Monkey
por: Yasuda, Masaharu, et al.
Publicado: (2010)

Neuronal correlates of functional magnetic resonance imaging in human temporal cortex
por: Ojemann, George A., et al.
Publicado: (2010)

THE MEDIAL ENTORHINAL CORTEX IS NECESSARY FOR TEMPORAL ORGANIZATION OF HIPPOCAMPAL NEURONAL ACTIVITY
por: Schlesiger, Magdalene I., et al.
Publicado: (2015)

Neuronal populations in the occipital cortex of the blind synchronize to the temporal dynamics of speech
por: Van Ackeren, Markus Johannes, et al.
Publicado: (2018)

Color Tuning of Face-Selective Neurons in Macaque Inferior Temporal Cortex
por: Duyck, Marianne, et al.
Publicado: (2021)

MicroRNA and mRNA Expression Changes in Steroid Naïve and Steroid Treated DMD Patients
por: Liu, Da Zhi, et al.
Publicado: (2015)

Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain
por: Zhan, Xinhua, et al.
Publicado: (2015)

Bacterial lipopolysaccharide is associated with stroke
por: Hakoupian, Marisa, et al.
Publicado: (2021)

Methamphetamine-Induced Neuronal Damage: Neurotoxicity and Neuroinflammation
por: Kim, Buyun, et al.
Publicado: (2020)

Exosomes as mediators of neuron-glia communication in neuroinflammation
por: Pascual, María, et al.
Publicado: (2019)

Converging Neuronal Activity in Inferior Temporal Cortex during the Classification of Morphed Stimuli
por: Akrami, Athena, et al.
Publicado: (2009)

Temporal structure in neuronal activity during working memory in Macaque parietal cortex
por: Pesaran, B, et al.
Publicado: (2000)

The impact of orientation filtering on face-selective neurons in monkey inferior temporal cortex
por: Taubert, Jessica, et al.
Publicado: (2016)

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD
por: Kim, Dae-Sung, et al.
Publicado: (2014)

Neuron-Specific Enolase (NSE) as a Biomarker for Autistic Spectrum Disease (ASD)
por: Stancioiu, Felician, et al.
Publicado: (2023)

Comparison of the Upper Marginal Neurons of Cortical Layer 2 with Layer 2/3 Pyramidal Neurons in Mouse Temporal Cortex
por: Luo, Huan, et al.
Publicado: (2017)

Intracerebral Hemorrhage and Ischemic Stroke of Different Etiologies Have Distinct Alternatively Spliced mRNA Profiles in the Blood: a Pilot RNA-seq Study
por: Dykstra-Aiello, Cheryl, et al.
Publicado: (2015)

Acute Colon Inflammation Triggers Primary Motor Cortex Glial Activation, Neuroinflammation, Neuronal Hyperexcitability, and Motor Coordination Deficits
por: Carrascal, Livia, et al.
Publicado: (2022)

Microglial activation in the motor cortex mediated NLRP3-related neuroinflammation and neuronal damage following spinal cord injury
por: Hu, Xvlei, et al.
Publicado: (2022)

Visual Working Memory and Delay Activity in Highly Selective Neurons in the Inferior Temporal Cortex
por: Sigala, Natasha
Publicado: (2009)

Neuronal coding of multiscale temporal features in communication sequences within the bat auditory cortex
por: García-Rosales, Francisco, et al.
Publicado: (2018)

Searching for visual features that explain response variance of face neurons in inferior temporal cortex
por: Owaki, Takashi, et al.
Publicado: (2018)

Distinct neuronal types contribute to hybrid temporal encoding strategies in primate auditory cortex
por: Liu, Xiao-Ping, et al.
Publicado: (2022)

Neurons in inferior temporal cortex are sensitive to motion trajectory during degraded object recognition
por: Burk, Diana C, et al.
Publicado: (2022)

NRXN1α(+/-) is associated with increased excitability in ASD iPSC-derived neurons
por: Avazzadeh, Sahar, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_37nb91j86htea8mgrfira7iqbb